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Thermo Fisher

Scientist, LC-MS Bioanalysis

Cambridge, Massachusetts, USA Full time

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Office

Job Description

Scientist, LC-MS Bioanalysis

Job Description

Role: Scientist

This is a fully onsite role based at our customer’s site in Cambridge, MA.
We welcome applicants from all locations within the US. Please note that relocation assistance is not provided for this position, and any relocation costs will be the responsibility of the candidate. 

Must be legally authorized to work in the United States without sponsorship.

Must be able to pass a comprehensive background check, which includes a drug screening.

At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.

Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

The non-clinical bioanalytical team within TMU LabSci at our client site, is searching for an insourced worker to join the team, conducting custom bioanalysis for research and development purposes. Assay applications will include pharmacokinetic (PK) and pharmacodynamic (PD) assays in a non-regulated setting using mass spectrometry.

This is a 100% lab-based and onsite role.

 Key Responsibilities Include:

  • Assist in setting up bioanalytical workflows by working with lead scientist and group head.
  • Design, develop and qualify PK assays in preclinical setting.
  • Work on simple or complex biologics, and oligonucleotide bioanalysis
  • Develop sample preparation approaches such as protein precipitation, solid phase extraction, Immunoprecipitation, enzymatic digestions etc.
  • Develop LC-MS/MS and LC-HRMS for intact protein analysis, middle-up approach or bottom-up approach.
  • Use these methods to characterize pharmacokinetic profile of constructs, including integrity analysis.
  • Coordinate outsourcing activities at CRO by monitoring method development, qualification and sample analysis by LC-MS and LBA.
  • May work on immunoassay methods using techniques such as MSD.
  •  Report and discuss bioanalytical results with integrative knowledge of how the data contributes to the drug development process.
  •  Actively contribute to scientific discussions.

Qualifications:  

Education and Experience:

  • Bachelor's degree in lab sciences such as  biochemistry, biotechnology, pharmaceutical sciences or related health sciences with 2-4 years of previous experience that provides the knowledge, skills, and abilities to perform the job OR Masters degree in above lab science degrees with 1+ years of experience.
  • Has at least 2 years of experience working in a bioanalytical lab.

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Knowledge, Skills and Abilities

  • Experience in various mass spectrometry platforms, including high resolution mass spectrometry (time of flight and orbitrap) and triple quadrupole mass spectrometry
  • Good understanding of protein analysis on platforms such as Thermo, Waters, Sciex.
  • Experience with different extraction techniques for quantitation of proteins in biological matrices (plasma and tissues).
  • Knowledge of proteomics tools such as handling queries on protein databases and protein sequence analysis.
  • Preferred to have working experience on ligand binding assays.
  • Ability to write scientific documents, including project team documents and study reports.
  • Ability to identify solutions to challenges scientifically and through inter-personal skills.
  • Scientific curiosity, appetite for teamwork and problem-solving skills

Working Environment:

  • Below is listed the working environment/requirements for this role:
  • Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
  • Able to work upright and stationary and/or standing for typical working hours.
  • Able to lift and move objects up to 25 pounds
  • Able to work in non-traditional work environments.
  • Able to use and learn standard office equipment and technology with
  • proficiency.
  • May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
  • Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

Compensation and Benefits

The hourly pay range estimated for this position based in Massachusetts is $30.00–$34.00.

This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

  • A choice of national medical and dental plans, and a national vision plan, including health incentive programs

  • Employee assistance and family support programs, including commuter benefits and tuition reimbursement

  • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy

  • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan

  • Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards