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The Analytical Development Synthetic Molecules Structural Characterization (ADSMUS-SC) team is responsible for providing an understanding of the structure of drug molecules and impurities, degradants and other components of interest that may be present during the preparation of drug substances and drug products. The team utilizes advanced analytical technologies (NMR, MS, HPLC, etc) to determine the molecular structure of these compounds to assist in process optimization, method development, and regulatory filing.
The individual selected for this position will explore the use of miniaturized analytical instruments to assist in the characterization of a range of different types of molecules from the Takeda pipeline. These include miniaturized LC and MS instruments, benchtop NMR, as well as their full-size counterparts. The improvement to the environmental impact of these miniaturized instruments will also be assessed to gain an understanding of their impact on the company’s carbon footprint.
How You Will Contribute:
As an Analytical Development Synthetic Molecules Structural Characterization Intern, you will have the opportunity to…
Use cutting-edge LC-MS and NMR technology for structural characterization as well as process analytical technology for reaction monitoring.
Configure an interface between a miniature LC and an MS detector, including the fluidic transfer lines and control software. The interface should enable fluid transfer from the mini-LC to the MS for structural characterization and offline reaction monitoring and allow for trigger concurrent data acquisition.
Collaborate with process chemists to apply the mini-LC-MS system to reaction monitoring for the quantitation of byproducts/impurities in complex reaction mixtures, with UV and/or MS2 quantification. Compare UV and MS based quantification with that provided by NMR.
Collaborate with process chemists to build a sampling system with commercially available components such as externally controlled valves. The sampling system should feed (in mL/min flow rate) the reaction mixture to the MS and/or NMR alone for online reaction monitoring.
Develop data processing tools to integrate the LC, MS, and NMR data into a single file and store to an appropriate database for future reference/recall.
Internship Development Opportunities:
The intern will gain hands-on access to a modern Analytical Laboratory with cutting- edge instrumentation for structural characterization.
The intern will gain experience working in a collaborative industrial analytical laboratory to solve challenging structural chemistry problems.
The intern will gain experience working in a fast-paced pharmaceutical environment and gain an understanding of the drug development process.
Job Requirements:
This position will be Fully On-Site at the Cambridge, MA - Kendall Square location.
The candidate must be currently pursuing a bachelor’s degree in chemistry, Biochemistry, Chemical Engineering or a closely related discipline.
Completion of coursework in Analytical Chemistry (with lab) and Organic Chemistry (with lab) or the equivalent are required.
Experience using advanced instrumentation (NMR, MS, LC, etc) for structural characterization is highly desired.
Experience with computer programming in a modern programming language is also highly desired.
Internship Eligibility
Must be authorized to work in the U.S. on a permanent basis without requiring sponsorship
Must be currently enrolled in a degree program graduating December 2026 or later
The internship program is 10-12 weeks depending on the two start dates (May 26th-August 14th or June 15th- August 21st)
The intern must be able to commit to one of these time frames
Able to work full time 40 hours a week during internship dates
Takeda does not provide a housing stipend or relocation support for the U.S Summer Internship Program
Program Highlights:
Hands-on experience with real projects and responsibilities
Dedicated mentorship program pairing interns with experienced professionals
Networking opportunities with industry professionals and fellow interns
Internship events focused on professional and skills development
Exposure to multiple business areas or departments within a Pharmaceutical Organization
Applications will be accepted between November 7th - November 30th
Takeda Compensation and Benefits Summary
We understand compensation may be an important factor as you consider an internship opportunity. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MAU.S. Hourly Wage Range:
$21.00 - $46.00
The estimated hourly range reflects an anticipated range for this position. The actual hourly wage offered will depend on the candidate’s school year/level to be entered following completion of internship. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. internship benefits vary by location and may include:
Paid sick time
Civic Duty paid time off
Participation at company volunteer events
Participation at company sponsored special events
Access to on-site fitness center (where available)
Commuter Benefit: To offset your work-commute expenses, Takeda provides U.S. employees with a fixed monthly subsidy to be used for either public transportation (transit) or parking.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Job Exempt
NoIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.